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In a study reported inwards the Journal of the National Cancer Institute, Cives et al flora that postsurgical relapse occurred inwards 31% of patients with phase I to III midgut neuroendocrine tumors over long-term follow-up, with liver, mesentery, in addition to pelvic lymph nodes beingness the principal sites of relapse.
Characteristics of Recurrence
The retrospective study included 129 patients treated at the Moffitt Cancer Center betwixt 2000 in addition to 2010 who underwent R0/R1 resection. Median postoperative follow-up was 81 months (range = 1–295 months). Recurrence was flora inwards twoscore patients (31.0%). Most recurrences were metastatic, with the liver (52.5%) in addition to pelvic lymph nodes (15.0%) beingness the nigh mutual sites of distant relapse. Locoregional recurrences were observed inwards thirteen patients (33.5%), with xi observed inwards the mesentery in addition to 2 inwards the small-scale intestine.
Median disease-free survival was 138 months. Resection of ≤ 17 lymph nodes predicted relapse (P = .01) in addition to shorter disease-free survival (median = 134 months vs non reached, P = .04). Among patients with relapse, the cumulative adventure of recurrence at 1, 5, in addition to ten years was 15.0%, 50.0%, in addition to 85.0%, respectively. No recurrences were observed with vi patients with phase I disease, whereas like rates of relapse were noted with the 118 with phase II (35.7%) or III illness (31.7%).
The investigators concluded: “An annual surveillance interval may permit early on detection of recurrence. Given the apparent refuse inwards recurrence afterwards 8 years from surgery, a decade-long duration of active surveillance may hold upwardly proposed.”
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