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In a study reported inward the Journal of the National Cancer Institute, Cives et al works life that postsurgical relapse occurred inward 31% of patients alongside phase I to III midgut neuroendocrine tumors over long-term follow-up, alongside liver, mesentery, as well as pelvic lymph nodes existence the top dog sites of relapse.
Characteristics of Recurrence
The retrospective study included 129 patients treated at the Moffitt Cancer Center betwixt 2000 as well as 2010 who underwent R0/R1 resection. Median postoperative follow-up was 81 months (range = 1–295 months). Recurrence was works life inward forty patients (31.0%). Most recurrences were metastatic, alongside the liver (52.5%) as well as pelvic lymph nodes (15.0%) existence the virtually mutual sites of distant relapse. Locoregional recurrences were observed inward xiii patients (33.5%), alongside eleven observed inward the mesentery as well as two inward the modest intestine.
Median disease-free survival was 138 months. Resection of ≤ 17 lymph nodes predicted relapse (P = .01) as well as shorter disease-free survival (median = 134 months vs non reached, P = .04). Among patients alongside relapse, the cumulative lead chances of recurrence at 1, 5, as well as 10 years was 15.0%, 50.0%, as well as 85.0%, respectively. No recurrences were observed amid half dozen patients alongside phase I disease, whereas like rates of relapse were noted amid the 118 alongside phase II (35.7%) or III illness (31.7%).
The investigators concluded: “An annual surveillance interval may permit early on detection of recurrence. Given the apparent spend upwards inward recurrence later 8 years from surgery, a decade-long duration of active surveillance may live on proposed.”
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